![First Response pregnancy tests quick and over 99% accurate from the day of your expected period. [2]](https://m.media-amazon.com/images/S/aplus-media/vc/117c7212-2afa-42d2-82b9-e2dbc44bede4.__CR0,0,1500,1500_PT0_SX220_V1___.jpg)
![Detects 4 Major Forms hCG all major pregnancy hormones commonly found urine. Use as directed. [3]](https://m.media-amazon.com/images/S/aplus-media/vc/cdfa1cc3-8113-4b0a-945a-6e678587bbaa.__CR0,0,1500,1500_PT0_SX220_V1___.jpg)
I decided to post some data about this FRER sensitivity for those of you who are like me wonders how the test reflects the actual HCG concentrations. I made serial dilutions of human recombinant HCG (Novarel), that I had some leftovers of after my IVF cycle. The dilutions were made with lab pipets, so the concentration should be pretty precise, and in the appropriate buffer (sorry for the details, that was my husband's urine) to model the amount of HCG in the urine for the test. Here are results (see photos attached too).
At 5 mU/ml, which is below the threshold of 6 mU/ml ( the sensitivity, claimed by the brand), the test is very-very faint. However, I would consider it positive, because just husband's urine only gives no second line at all (I do not have photo for this, we did it some time ago with our first unsuccessful transfer, when I had chemical pregnancy). 5 mU/ml in your first morning urine is equal about 10-15 mU/ml in blood, so this is comparable to 5-4 days before your missed period. Also, compare the 5 mU/ml results with my actual results for 8 days post transfer of 6-day blastocyst (last picture), two days later at 10dpt I had blood beta-HCG level of 38.
At 20 mU/ml we can see clear positive results. This is HCG level that you will have at your first day of missed period, and equals to about 40-60 mU/ml of beta-HCG in blood.
And only at 100 mU/ml we see the second line at the same brightness as the control line. I would say at this HCG level the FRER test reaches it's saturation point.
Also, I found out that you may use LH tests (used for ovulation detection) instead of HCG for the early results. LH tests are very sensitive, looks like even more sensitive than FRER (you can see how much darker the test line is for the 5 mU/ml sample). I could not find an information about what subunit of LH these tests are detecting, my understanding it is beta-subunit of LH which is nearly identical in structure to beta-subunit of HCG. Beta-HCG, however, has about 30 additional amino acids, so home pregnancy tests designed to pick up beta-HCG only, while home ovulation tests will pick up both. After ovulation and during pregnancy LH levels are down, so in my opinion you can easily use you LH leftover test to monitor HCG levels, at least to see how it doubles, for example.
Another observation for FRER, these tests tend to get darker with time. If your HCG levels are expected to be below or around the threshold (like day 6 post IVF transfer or so), and the test line does not show up, I suggest you keep the test for another 24 h and you may see faint positive later.
For those users, who claim about "false" positive FRER results. As my experiments with my husband's urine proved, if you do not have HCG, the test will be clear negative - no test line at all, only control line. If you see faint positive, which lately with another test disappeared, or if your period came, that means you had so called chemical pregnancy. It might be devastating, I understand, we had a chemical with our first failed IVF cycle. But this is a drawback of using very sensitive test, so just be prepared.
To summarize my experiment: FRER is very sensitive, it shows faint positive even below claimed threshold, however good positive results are at about 20 mU/ml, or your first day of missed period. I give only 4 stars for these tests because of the idiotic curved handle - it is completely unnecessary design, makes it difficult to lay flat, and takes more space in the drawer if you want to keep the used test for future reference.
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From the manufacturer
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| First Response Early Result Pregnancy Tests | First Response Gold Pregnancy Test 2ct | First Response Rapid Result Pregnancy Test | First Response Test & Confirm Pregnancy Test 2 ct | |
| Contents | 2 pregnancy tests or 3 pregnancy tests | 2 pregnancy tests | 2 pregnancy tests | 1 Early Result Pregnancy Test and 1 Gold Digital Pregnancy Test |
| Display Method | Line Test | Digital 'Yes+/-No' | Digital 'Yes+/-No' and Line Test | |
| Disclaimers | (1)First Response detects the pregnancy hormone 6 days sooner than the day of your missed period (5 days before the day of expected period). | |||
| (2) Over 99% accurate at detecting typical pregnancy hormone levels. Note that hormone levels vary. | ||||
| (3) First Response Early Result and Gold Digital detect all of the major pregnancy hormone forms commonly found in urine. Use as directed. | ||||
| (4) Nielsen AOC Diagnostics Database as of 7.15.17. | ||||
| (5) US News and World Report, Pharmacy Times, Survey of Pharmacists’ OTC Recommendations, Ovulation Prediction, 2017. | ||||
| (6) Sooner than without ovulation testing when directions are carefully followed. | ||||
| (7) Over 99% accurate in detecting the LH surge in laboratory studies. | ||||
| (8) Minkin MJ. Embryonic development and pregnancy test sensitivity: the importance of earlier pregnancy detection. Women's Health (Lond Engl). 2009 Nov, 5(6):659-67. |
Compare with similar items
 | AccuMed Pregnancy Test Strips, 25-Count Individually Wrapped Pregnancy Strips, Early Home Detection Pregnancy Test Kit, Clear HCG Test Results, Over 99% Accurate | Clearblue Clearblue Pregnancy Test Combo Pack, 4ct - 2 Digital with Smart Countdown & 2 Rapid Detection - Value Pack | First Response Early Result Pregnancy Test, 3 Count (Packaging & Test Design May Vary) | Easy@Home 50 Ovulation Test Strips and 20 Pregnancy Test Strips Combo Kit, (50 LH + 20 HCG) | Clearblue Early Detection Pregnancy Test, 3ct | |
|---|---|---|---|---|---|---|
| Customer Rating | (26800) | (23801) | (11489) | (1571) | (49813) | (4379) |
| Price | $12.98 | $9.99 | $16.94 | $12.98 | $16.99 | $12.98 |
| Shipping | FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime | FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime | FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime | FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime | FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime | FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime |
| Sold By | Amazon.com | BNX AccuMed | Amazon.com | Amazon.com | Easy@Home | Amazon.com |
| Brand Name | FIRST RESPONSE | AccuMed | Clearblue | FIRST RESPONSE | Easy@Home | Clearblue |
| Size | 3 Count (Pack of 1) | 25 Count (Pack of 1) | 4 Count (Pack of 1) | 3 Count (Pack of 1) | 70 Piece Set | 3 Count (Pack of 1) |
Customer reviews
FRER sensitivity - checked with precise HCG concentrations
Reviewed in the United States on June 4, 2017
I decided to post some data about this FRER sensitivity for those of you who are like me wonders how the test reflects the actual HCG concentrations. I made serial dilutions of human recombinant HCG (Novarel), that I had some leftovers of after my IVF cycle. The dilutions were made with lab pipets, so the concentration should be pretty precise, and in the appropriate buffer (sorry for the details, that was my husband's urine) to model the amount of HCG in the urine for the test. Here are results (see photos attached too).At 5 mU/ml, which is below the threshold of 6 mU/ml ( the sensitivity, claimed by the brand), the test is very-very faint. However, I would consider it positive, because just husband's urine only gives no second line at all (I do not have photo for this, we did it some time ago with our first unsuccessful transfer, when I had chemical pregnancy). 5 mU/ml in your first morning urine is equal about 10-15 mU/ml in blood, so this is comparable to 5-4 days before your missed period. Also, compare the 5 mU/ml results with my actual results for 8 days post transfer of 6-day blastocyst (last picture), two days later at 10dpt I had blood beta-HCG level of 38.At 20 mU/ml we can see clear positive results. This is HCG level that you will have at your first day of missed period, and equals to about 40-60 mU/ml of beta-HCG in blood.And only at 100 mU/ml we see the second line at the same brightness as the control line. I would say at this HCG level the FRER test reaches it's saturation point.Also, I found out that you may use LH tests (used for ovulation detection) instead of HCG for the early results. LH tests are very sensitive, looks like even more sensitive than FRER (you can see how much darker the test line is for the 5 mU/ml sample). I could not find an information about what subunit of LH these tests are detecting, my understanding it is beta-subunit of LH which is nearly identical in structure to beta-subunit of HCG. Beta-HCG, however, has about 30 additional amino acids, so home pregnancy tests designed to pick up beta-HCG only, while home ovulation tests will pick up both. After ovulation and during pregnancy LH levels are down, so in my opinion you can easily use you LH leftover test to monitor HCG levels, at least to see how it doubles, for example.Another observation for FRER, these tests tend to get darker with time. If your HCG levels are expected to be below or around the threshold (like day 6 post IVF transfer or so), and the test line does not show up, I suggest you keep the test for another 24 h and you may see faint positive later.For those users, who claim about "false" positive FRER results. As my experiments with my husband's urine proved, if you do not have HCG, the test will be clear negative - no test line at all, only control line. If you see faint positive, which lately with another test disappeared, or if your period came, that means you had so called chemical pregnancy. It might be devastating, I understand, we had a chemical with our first failed IVF cycle. But this is a drawback of using very sensitive test, so just be prepared.To summarize my experiment: FRER is very sensitive, it shows faint positive even below claimed threshold, however good positive results are at about 20 mU/ml, or your first day of missed period. I give only 4 stars for these tests because of the idiotic curved handle - it is completely unnecessary design, makes it difficult to lay flat, and takes more space in the drawer if you want to keep the used test for future reference.
Reviewed in the United States on June 4, 2017
Images in this review
Top reviews from the United States
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Reviewed in the United States on June 4, 2017
At 5 mU/ml, which is below the threshold of 6 mU/ml ( the sensitivity, claimed by the brand), the test is very-very faint. However, I would consider it positive, because just husband's urine only gives no second line at all (I do not have photo for this, we did it some time ago with our first unsuccessful transfer, when I had chemical pregnancy). 5 mU/ml in your first morning urine is equal about 10-15 mU/ml in blood, so this is comparable to 5-4 days before your missed period. Also, compare the 5 mU/ml results with my actual results for 8 days post transfer of 6-day blastocyst (last picture), two days later at 10dpt I had blood beta-HCG level of 38.
At 20 mU/ml we can see clear positive results. This is HCG level that you will have at your first day of missed period, and equals to about 40-60 mU/ml of beta-HCG in blood.
And only at 100 mU/ml we see the second line at the same brightness as the control line. I would say at this HCG level the FRER test reaches it's saturation point.
Also, I found out that you may use LH tests (used for ovulation detection) instead of HCG for the early results. LH tests are very sensitive, looks like even more sensitive than FRER (you can see how much darker the test line is for the 5 mU/ml sample). I could not find an information about what subunit of LH these tests are detecting, my understanding it is beta-subunit of LH which is nearly identical in structure to beta-subunit of HCG. Beta-HCG, however, has about 30 additional amino acids, so home pregnancy tests designed to pick up beta-HCG only, while home ovulation tests will pick up both. After ovulation and during pregnancy LH levels are down, so in my opinion you can easily use you LH leftover test to monitor HCG levels, at least to see how it doubles, for example.
Another observation for FRER, these tests tend to get darker with time. If your HCG levels are expected to be below or around the threshold (like day 6 post IVF transfer or so), and the test line does not show up, I suggest you keep the test for another 24 h and you may see faint positive later.
For those users, who claim about "false" positive FRER results. As my experiments with my husband's urine proved, if you do not have HCG, the test will be clear negative - no test line at all, only control line. If you see faint positive, which lately with another test disappeared, or if your period came, that means you had so called chemical pregnancy. It might be devastating, I understand, we had a chemical with our first failed IVF cycle. But this is a drawback of using very sensitive test, so just be prepared.
To summarize my experiment: FRER is very sensitive, it shows faint positive even below claimed threshold, however good positive results are at about 20 mU/ml, or your first day of missed period. I give only 4 stars for these tests because of the idiotic curved handle - it is completely unnecessary design, makes it difficult to lay flat, and takes more space in the drawer if you want to keep the used test for future reference.
Size: 3 Count (Pack of 1)Verified Purchase
FRER sensitivity - checked with precise HCG concentrations
Reviewed in the United States on June 4, 2017
I decided to post some data about this FRER sensitivity for those of you who are like me wonders how the test reflects the actual HCG concentrations. I made serial dilutions of human recombinant HCG (Novarel), that I had some leftovers of after my IVF cycle. The dilutions were made with lab pipets, so the concentration should be pretty precise, and in the appropriate buffer (sorry for the details, that was my husband's urine) to model the amount of HCG in the urine for the test. Here are results (see photos attached too).Reviewed in the United States on June 4, 2017
At 5 mU/ml, which is below the threshold of 6 mU/ml ( the sensitivity, claimed by the brand), the test is very-very faint. However, I would consider it positive, because just husband's urine only gives no second line at all (I do not have photo for this, we did it some time ago with our first unsuccessful transfer, when I had chemical pregnancy). 5 mU/ml in your first morning urine is equal about 10-15 mU/ml in blood, so this is comparable to 5-4 days before your missed period. Also, compare the 5 mU/ml results with my actual results for 8 days post transfer of 6-day blastocyst (last picture), two days later at 10dpt I had blood beta-HCG level of 38.
At 20 mU/ml we can see clear positive results. This is HCG level that you will have at your first day of missed period, and equals to about 40-60 mU/ml of beta-HCG in blood.
And only at 100 mU/ml we see the second line at the same brightness as the control line. I would say at this HCG level the FRER test reaches it's saturation point.
Also, I found out that you may use LH tests (used for ovulation detection) instead of HCG for the early results. LH tests are very sensitive, looks like even more sensitive than FRER (you can see how much darker the test line is for the 5 mU/ml sample). I could not find an information about what subunit of LH these tests are detecting, my understanding it is beta-subunit of LH which is nearly identical in structure to beta-subunit of HCG. Beta-HCG, however, has about 30 additional amino acids, so home pregnancy tests designed to pick up beta-HCG only, while home ovulation tests will pick up both. After ovulation and during pregnancy LH levels are down, so in my opinion you can easily use you LH leftover test to monitor HCG levels, at least to see how it doubles, for example.
Another observation for FRER, these tests tend to get darker with time. If your HCG levels are expected to be below or around the threshold (like day 6 post IVF transfer or so), and the test line does not show up, I suggest you keep the test for another 24 h and you may see faint positive later.
For those users, who claim about "false" positive FRER results. As my experiments with my husband's urine proved, if you do not have HCG, the test will be clear negative - no test line at all, only control line. If you see faint positive, which lately with another test disappeared, or if your period came, that means you had so called chemical pregnancy. It might be devastating, I understand, we had a chemical with our first failed IVF cycle. But this is a drawback of using very sensitive test, so just be prepared.
To summarize my experiment: FRER is very sensitive, it shows faint positive even below claimed threshold, however good positive results are at about 20 mU/ml, or your first day of missed period. I give only 4 stars for these tests because of the idiotic curved handle - it is completely unnecessary design, makes it difficult to lay flat, and takes more space in the drawer if you want to keep the used test for future reference.
Images in this review
Reviewed in the United States on October 3, 2019
Size: 3 Count (Pack of 1)Verified Purchase
Warning this is a fake test! I had one test left after buying from CVS. Took that and there was a line. With the same exact urine (dipped it) I took a test from the amazon shipment. Nothing. Then I took another thinking it was faulty. Nothing again. Finally I took that last one and realized how they looked compared to the REAL FRER test I bought from CVS. They are smaller, sounds like something is broken when shaken and the lines do not line up. Do not buy!!!!
Images in this review
Reviewed in the United States on January 6, 2019
Size: 3 Count (Pack of 1)Verified Purchase
I got my first positive test at 8 DPO (days past ovulation), which was 5 days before my period. As you can see from the picture, the line was darker on each consecutive day.
Every woman is different though. You'll only see a positive result once implantation happens for you, so if you get a negative at 8/9 DPO, maybe you haven't implanted yet or maybe you're not pregnant. You should just try again.
The reason I'm writing this review is because I think this product has been unfairly reviewed by women who tested too early and got false negative results. A couple of women also seemed to get "false positives" - although I'm sorry to say this is most likely the result of a chemical pregnancy, which I'm currently hoping is not going to be the case for me.
Every woman is different though. You'll only see a positive result once implantation happens for you, so if you get a negative at 8/9 DPO, maybe you haven't implanted yet or maybe you're not pregnant. You should just try again.
The reason I'm writing this review is because I think this product has been unfairly reviewed by women who tested too early and got false negative results. A couple of women also seemed to get "false positives" - although I'm sorry to say this is most likely the result of a chemical pregnancy, which I'm currently hoping is not going to be the case for me.
Images in this review
Reviewed in the United States on December 6, 2017
Size: 3 Count (Pack of 1)Verified Purchase
ALERT!! This seller has changed the item to ...
Reviewed in the United States on December 6, 2017
ALERT!! This seller has changed the item to First Response Pregnancy Pro now! Item received was not as described. I received the digital version of this product when the image in the listing clearly shows the original double line tests (without a digital readout)....and this is my SECOND time receiving it this way (bought last week from this seller also)!! The first test I used didn’t even display a result, which I why I wanted the non-digital version.
Reviewed in the United States on December 6, 2017
Images in this review
Top reviews from other countries
Louise
My favourite trusted brand
Reviewed in the United Kingdom on November 15, 2016Size: 3 Count (Pack of 1)Verified Purchase
D
Not 3 packs as per the title but one pack of 3
Reviewed in the United Kingdom on November 1, 2019Size: 3 Count (Pack of 1)Verified Purchase
Amazon Customer
Five Stars
Reviewed in the United Kingdom on October 13, 2016Size: 3 Count (Pack of 1)Verified Purchase
Alexandra Phasaria
Still the most accurate test out there!
Reviewed in Germany on February 13, 2019Size: 3 Count (Pack of 1)Verified Purchase