Overall, a pleasing film with a strong, but human female lead. At times, a bit too melodramatic -- although I don't suppose the average audience-member could be expected to become emotionally invested in the technicalities of radiation or the daily grind of doing science. Sometimes the choices of shots -- focusing on shoes, or confusing sequences of light and color -- felt like distractions from the narrative, but at times they did evoke some of the strange, eerie wonder of radioactivity and its effects.
Marie is very well-played by Rosamund Pike, but I felt the rest of the cast a bit subpar, and they seemed unnatural, possibly because of the "period" aspect. It was, at many times, difficult to believe in the periodicity of the characters besides Mdme. Curie, and many of them felt like caricatures -- the suggestions of stodgy old scientists or helpful lab assistants, little more than three-piece suits and false facial hair, expressing a single emotional note, rather than people. Other period elements -- the glow of gaslamps, the industrial grime of turn-of-the-20th-century Paris, the sooty beakers, the attire -- were atmospherically appropriate and gave a decent sense of time and place.
Though I'm not very familiar with the relationship between Pierre and Marie, and may be a bit cynical here, I found it unlikely that Pierre was quite so doting, in awe, and supportive of Marie and her work. Yes, they did work together, and yes, he did share the Nobel Prize with her, when he could have refused and insisted she retire to be a housewife. But marriages in this time were predominantly practical matters, and Pierre's eagerness to accommodate and encourage Marie feels, in this film, more of a modern fantasy of gender parity than a representation of fact. Even if that was their true dynamic, it feels out of step with Marie's personality, the colleague-like nature of their situation, and the time and place, so could have used more deliberate development.
Despite these issues, the film, overall, treated Marie Curie with respect, yet avoided placing her on a pedestal. She is portrayed, at times, as curt, rude, flippant, cold, unreasonable, an unrepentant adulteress, and not a particularly good mother. It is also heavily implied that she may bear part of the blame for the destructive applications of her work -- debatable, but certainly there is ambiguity about the "net good" her scientific legacy may have caused. She is also vulnerable to grief and pain -- and yet, despite these human frailties, she remains an intellectual powerhouse, determined in her work (and it clearly is work, and clearly requires determination -- it is no walk in the park) and conducting herself with dignity under hostile conditions.
Overall, the film manages a balance between admitting the humanity of Marie Curie while exalting her for her intellect, her hard work, and her perseverance as a woman in a time of significant sexism. It manages to inspire without being insipid, and is fine to look at, to boot. Not a bad way to spend a couple hours, especially for the uncommon chance to see such a strong, capable woman at work. Earnest reminders of such women are rare, but good for the soul. Not an excellent film, but a pretty good one.