Upgraded from a very old Performance MX mouse that started having issues, and I'm very disappointed with my experience so far with this mouse in Windows 10.
Ergonomically this mouse was not designed for my hand. The palm/knuckle section of the mouse sits very high, and feels awkward. The back/forward buttons are placed in a very awkward position that almost requires me to move my hand to get at them, I can't just roll my thumb over them anymore.
The worst issue I've been running into is with the "logitech options" software and it's pointer speed settings. Even at the highest speed the mouse is VERY slow. The only workaround I've found for this is to shut off the logitech software in task manager and set the mouse speed in "mouse properties" in the windows control panel (if you do not shut off the logitech software it will overwrite your settings). If you opt to shut off the Logitech software it will disable functionality like the middle button click, back/forward buttons, and the horizontal scroll wheel.