Splenda will increase your blood sugar, it has sugars in it It is a no-no for diabetics. Sucralose alone may increase your blood glucose and it can also interfere with prescription medications according to the FDA When I found that out I started looking for different sugar substitutes. The sweetener Xylitol has a very low glycemic index of 7vs regular sugar's 95-100. This gum is the absolute BEST !!!!!!!!!!! The flavor does not last as long as some of the other brands I won't chew anything else ever again. It is made with xylitol which is actually good for your teeth. I need to chew gum or suck on hard candy (sugarless of course) because my mouth is very dry. I have tried products that are specifically for dry mouth, but this gum tastes much better. I love the bubblegum flavor, it tastes just like regular bubble gum. I gave some to my great nephew who id 6 and he said "This tastes just like my gum" which was Double Bubble.